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Recombinant Mouse IL-13 (His Flag) is a cytokine used in biomedical research derived from mouse interleukin-13 and modified with His and Flag tags for purification and detection It plays a crucial role in immunological pathways primarily affecting the differentiation and activity of immune cells IL-13 is known to engage with the IL-13 receptor influencing various signaling cascades that regulate inflammation and immune responses In vitro this recombinant protein displays activity in the nanomolar to low micromolar range depending on the specific assay conditions It is widely applied in cell culture models to study immune modulation and is frequently used in animal models to investigate asthma and allergic responses Additionally it serves in drug screening processes aiming to find novel therapies targeting immune-related disorders Experimental concentrations of Recombinant Mouse IL-13 typically depend on the specific research design and objectives of the study
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Recombinant Human M-CSF/CSF1 (His Flag) is a crucial cytokine involved in the regulation of immune system functions Originating from human sources it plays a significant role in hematopoietic stem cell differentiation and macrophage lineage fate by binding to the CSF1 receptor Its mechanism of action involves the activation of signaling pathways that promote cell proliferation and survival This cytokine demonstrates potent activity in the nanomolar to low micromolar range when assessed in vitro It is commonly applied in cell models such as macrophage colony assays and utilized in animal studies to investigate immune responses and bone metabolism Additionally it serves an essential role in drug screening processes aimed at developing therapies for immune-related conditions Experimental concentrations typically depend on the specific research design
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A GPBAR1 antagonist inhibits taurolithocholic acid-induced increases in cAMP levels in and proliferation of cholangiocytes isolated from patients with autosomal dominant polycystic kidney disease at 100 and 200 UM decreases the viability of and protein levels of GPBAR1 in PANC-1 cells at 10 UM prevents B. pseudocatenulatum-induced decreases in serum levels of IFN-Y and IL-17A in a mouse model of collagen-induced arthritis at 80 mg/kg
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Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immune responses FGL2 is overexpressed in glioma and its expression level is negatively associated with the prognosis of glioma patients
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Recombinant Mouse IL-17 (His Flag) is a cytokine used in biomedical research particularly in immunology and inflammation studies Originating from mouse models it plays a crucial role in mediating pro-inflammatory responses by signaling through the IL-17 receptor pathway influencing downstream effects like cytokine production and cell recruitment This protein is commonly tested at nanomolar to low micromolar concentrations for its in vitro activity It is frequently used in cell models to study inflammatory pathways and in animal studies to explore its role in diseases like autoimmune disorders Additionally it serves as an important tool in drug screening for evaluating potential therapeutic interventions targeting IL-17 mediated pathways Experimental concentrations typically depend on the specific research design
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Recombinant Mouse IL-19 (His Flag) is a protein used in biomedical research derived from mouse sources It belongs to the IL-10 cytokine family and plays a role in immune response modulation by activating specific signaling pathways such as the JAK-STAT pathway Its activity is commonly noted in the nanomolar to low micromolar range This recombinant protein is frequently utilized in in vitro studies involving cell lines contributing to our understanding of immune signaling and cytokine interactions In vivo it is useful in animal model studies aimed at exploring inflammation-related conditions Additionally it aids in drug screening applications allowing researchers to evaluate potential therapeutic agents targeting inflammatory pathways Experimental concentrations typically depend on the specific research design ensuring precision and relevance to the study s objectives
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